Melanie Dee
Chem 241 Extra Credit
Acetyl salicylic acid
Aspirin is a medicine that relieve pain and reduces fever.

Aspirin is used to relieve many kinds of minor aches and pains—headaches, toothaches, muscle pain, menstrual cramps, the joint pain from arthritis, and aches associated with colds and flu. Some people take aspirin daily to reduce the risk of stroke, heart attack, or other heart problems.

Aspirin-also known as acetylsalicylic acid-is sold over the counter and comes in many forms, from the familiar white tablets to chewing gum and rectal suppositories. Coated, chewable, buffered, and extended release forms are available. Many other over-the-counter medicine contain aspirin. Alka-Seltzer Original Effervescent Antacid Pain Reliever, for example, contains aspirin for pain relief and sodium bicarbonate to relieve acid indigestion, heartburn, and sour stomach.
Aspirin belongs to a group of drugs called salicylates. Other members of this group include sodium salicylate, choline salicylate, and magnesium salicylate. These drugs are more expensive and no more effective than aspirin. However, they are a little easier on the stomach. Aspirin is quickly absorbed into the bloodstream and provides quick and relatively long-lasting pain relief. Aspirin also reduces inflammation. Researchers believe these effects come about because aspirin blocks the production of pain-producing chemicals called prostaglandins.
In addition to relieving pain and reducing inflammation, aspirin also lowers fever by acting on the part of the brain that regulates temperature. The brain then signals the blood vessels to widen, which allows heat to leave the body more quickly.

[not appropriate to copy abstract directly - use your own words JCB]

I found a paper on “Time Related Neutralization of Two Doses Acetyl Salicylic Acid” Aspirin has a well established role in the prevention of arterial thrombosis. Discussion on the efficacy and safety of aspirin in the treatment and prophylaxis of thrombosis has become an important issue. In fact, hemorrhage complications are often associated with its use. On the other hand, previous studies showed unexpected thrombotic potencies associated with the presence of this drug at ultra low doses (ULD) in the circulation. In this study, we aimed to evaluate the effect of aspirin at ULD, injected 1, 2, or 3 hours after the administration of aspirin at 100 mg/kg, on hemostasis and bleeding in rats. We used an experimental model of thrombosis induced by laser beams to evaluate these effects. Platelet aggregation was determined by Cardinal and Flower method. Results from this investigation demonstrate that the neutralizing effect of aspirin at ULD did not operate significantly 1 hour after the injection of aspirin at 100 mg/kg. This effect was observed 2 and 3 hours after. The use of aspirin at ULD to neutralize the side effects of aspirin at high doses will reduce the hemorrhagic risk during extra corporeal circulation. The therapeutic benefit and safety of aspirin therapy in the treatment of cardiovascular diseases can be obtained.



Paper: http://www.sciencedirect.com.ezproxy2.library.drexel.edu/science/article/pii/S0049384800003364